HSHS St. John’s Hospital in Springfield, Illinois is a regional medical center offering a comprehensive array of health care services to central and southern Illinois. Founded in 1875, St. John’s is the flagship hospital of Hospital Sisters Health System and is home to the Prairie Heart Institute, St. John’s Children’s Hospital, Women and Infants Center, Neurosciences Center, Women and Children's Clinic, Cancer Center, orthopedic services and AthletiCare.